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HGF/c-MET has been extensively studied as a therapeutic target in various cancers for the last two decades, especially in lung cancer therapy

This part will discuss recent data from literature regarding desensitization of the different OR: the impact of the agonist used through the notion of biased agonism, the role of phosphorylation and consequently the kinases involved, the implication of arrestins and OR internalization and their fate after endocytosis