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The images (Figure 6) showed that the nanocapsule did not penetrate the skin carrying the vitamin, but a deep permeation (around 30 m) of both was observed, which suggests that the drug present in deep skin layers was released from nanocapsules in the superficial skin layers

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Fasted-state dosing eliminates dietary nicotinamide competition for NNMT binding sites, increasing effective dose by 3542% compared to post-meal administration

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