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Psychol Rep

This was thought to explain the conservation of ethanol active ADH in species other than yeast, though ADH-3 is now known to also have a major role in nitric oxide signaling

For animal experiments, SD rat kidney sections were stained with CD68 for macrophage labeling and CD86 for M1 polarization marker validation

The indirect role of ADH5 in NO homeostasis has prompted the development of pharmacological inhibitors that might be used for the treatment of inflammatory diseases 50

Reduced FH expression leads to the accumulation of HIF-1 699 and high levels of fumarate, a cancer-associated oncometabolite, often resulting in cellular dysfunction in SDH- or FH-deficient cells