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Diabetologia 49 , 289297 (2006)

Furthermore, our study reveals that metformin can alleviate ECM degradation and inflammation in chondrocytes exposed to H 2 O 2 by reducing oxidative stress-induced damages Additionally, our results establish that metformin exerts its antioxidant effects mainly through the Nrf2 signaling pathway, ultimately slowing OA progression (Fig

The low diversity of mechanisms of action of current treatments represents a problematic situation when fungal pathogens are multi-resistant to antifungals (Rautenbach et al., 2016)