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doi:10.1001/jama.2020.22258 Basile J, Bloch MJ

The cells (1.5 10 4 cells/well) were seeded into 96-well plates and adhered for about 8 h before being exposed toward different concentrations of CoNPs (20800 M) for 824 h at 37 C to explore the IC50 value

The proposed mechanism involves direct interaction between the AEDG sequence and histones H1/3 and H1/6 a form of epigenetic regulation in which the peptide modulates chromatin accessibility at specific gene loci, thereby influencing transcriptional activity without altering the underlying DNA sequence (9)