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They used different concentrations of ARA-290 or a control solution on the murine models' hind appendages

2024;13 doi: 10.3390/foods13121853

The subsequent antigen presentation triggers the activation of Th1 and Th17 cells, leading to the release of pro-inflammatory cytokines (IL-2, TNF-, IFN-, IL-17), which in turn amplify oxidative stress and perpetuate an amplifying loop of inflammation and tissue damage (Kubiak et al