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Gluckman, P

This happens because B12 is important for nerve health and red blood cell production, and deficiency may lead to nerve irritation and fatigue in muscles

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FEBS Lett 581:31313138 Gulyas Z, Boldizsar A, Novak A, Szalai G, Pal M, Galiba G, Kocsy G (2014) Central role of the flowering repressor ZCCT2 in the redox control of freezing tolerance and the initial development of flower primordia in wheat

Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes