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ET50 was the inter-study variability of ET 50

146 With SGLT2i administration, proposed mechanisms that alter the insulin:glucagon ratio include loss of paracrine inhibition by insulin during euglycaemia, resulting in increased endogenous glucose production, increased glucagon secretion, reduced tissue glucose disposal, insulinopenia and elevations in plasma cortisol and catecholamines (Figure 16)

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Using DHEA over a long period or at high doses may be associated with cancer, and short-term use at low doses may lead to side effects such as acne, insomnia, mood changes, headache, and stomach upset