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Additionally, the high levels of LA, low pH, hypoxia, and reactive oxygen species (ROS) prevalent in the TME can impair T cells and natural killer cells while polarizing tumor-associated macrophages into a pro-tumoral M2-like phenotype, collectively facilitating immune evasion [20]

This comprehensive metabolic shift results in enhanced lipid utilization (lower cellular fat accumulation) and an efficient use of nutrients, echoing the metabolic effects of calorie restriction or exercise at the cellular scale

Masking of polar functional improves oral bioavailability [23]

The amount gradually declines as people age, with barely any difference between men and women by the time menopause begins

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