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Bitian Liu, [email protected];[email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The increased red pulp cell count within Chitosan@DOTAGA-treated mice may be evidence of either an altered blood supply, which is in agreement with the other histopathological observations of mice organs made within this study, or an intensification of the hemopoiesis suffering due to heavy metal exposure 53

MA, medial artery

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