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Prior research has suggested that the pathogenesis of DN involves the interplay of various metabolic and hemodynamic factors, including hyperglycemia, AGEs, and the renin-angiotensin system (RAS) (Tang et al., 2022

Finally, the review outlines the current knowledge gaps relating to the mechanisms by which peroxisome dynamics and inter-organelle interactions influence neuronal (dys)function, proposing potential new research directions to address these and further our understanding of the multi-faceted roles peroxisomes play in brain health and disease

We show that pathways such as host purine and heme biosynthesis are essential for both Theileria survival and Plasmodium liver development, while genes involved in glutathione and polyamine biosynthesis are predicted to be essential for Plasmodium only under certain metabolic conditions

Al-Jaf S, Soliman AY, El-Yazbi AF, Abd-Elrahman KS (2025) Unveiling the interplay: neurovascular coupling, astrocytes and g protein-coupled receptors in Alzheimers disease