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While capable of converting immunologically cold tumors and enhancing checkpoint blockade efficacy, it requires precise modulation to avoid immunosuppressive counteradaptations [147]

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Alcohol administration in mice in the NIAAA model resulted in a significant reduction in the genus Akkermansia [191] and oral administration of Akkermansia muciphila in the Lieber-DeCarli model ameliorated features of ALD [192]

For a better characterization of the relation between stress and the neuroendocrine system, the concept of allostatic load has been proposed

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