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Whereas the oxidation of selenenic acid to seleninic acid is reversible in the presence of GSH, the further oxidation to selenonic acid may inactivate the enzyme

For example, it converts toxic ammonia into urea, which is excreted in the urine

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Fibrotic programming is strongly correlated with CKD progression, which typically precedes an apparent reduction in GFR (24)

To date, previously unknown drugdrug interactions have been successfully identified by analyzing the information from these databases (Zhao et al., 2013