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2a, b), which was comparable to that observed in the livers of HFD-fed mice (Fig

Furthermore, combining butyrate with other therapeutic agents, such as targeted medications or microbiota-based interventions, may lead to synergistic effects and improved treatment outcomes

Mechanistically, MBOAT1/2, which are lyso-PL acyltransferases (LPLATs), change monounsaturated fatty acids (MUFAs) into lyso-phosphatidylethanolamines (lyso-PEs), increasing the levels of PE-MUFAs and decreasing the levels of PE-PUFAs to suppress phospholipid peroxidation and inhibit ferroptosis [91]

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doi: 10.3390/cancers15215274 234 YamamotoA.KawashimaA.UemuraT.NakanoK.MatsushitaM.IshizuyaY.et al