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[57] Long-term nicotine exposure upregulates cortical nicotinic receptors, but it also lowers the activity of the nicotinic receptors in the cortical vasodilation region

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But so far, nobody is making compelling points to counter the two biggest drawbacks of this, which are that prohibition has never worked and that criminalizing menthol cigarettes will almost certainly end up landing more people in jail over the sale, distribution or use of a controlled substance