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16 , 637647.e13 (2018)

Following endogenous growth hormone release, downstream production of insulin-like growth factor-1 (IGF-1) contributes to many of the physiological processes associated with growth hormone biology

Delves P, Roitt I

In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Teratani et al., 2017)