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Upon NADPH binding, the nicotinamide moiety inserts between FAD and Phe198 forming an aromatic sandwich in which the phenyl ring lays parallel to the FAD (Figure 2B)

[DOI] [PubMed] [Google Scholar] [10].Kang SS, Wong PWK, Malinow MR

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Therefore, the decrease in both the reaction rate and yield could be caused by a decrease in NsPCS activity