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Using this assay to analyze plasma samples from NKTL patient 1, we estimated the amount of circulating Daratumumab in this patient to be 625, 25 and 2.5 ug/ml at 2 weeks (tp0), 7 weeks (tp1) and 13 wpD treatment (tp2) respectively

However, its intrinsic physicochemical drawbacks, including poor aqueous solubility and high susceptibility to oxidative degradation, pose major challenges for its biomedical application [302]

Neuroinflammation 14 , 261 (2017)

The preclinical window of dopaminergic decline prior to symptom emergence is estimated at 6 3 years using imaging, [113] whereas estimates from nigral cell counts set this period at an average 4.5 years