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This is the body adjusting to GLP-1 and GIP receptor activation, particularly the slowed gastric emptying that GLP-1 produces

Additionally, some who take Metformin experience vitamin B12 deficiency , though its important to note that B12 deficiency may not be directly caused by Metformin

Its so common that patients often dont recognize the symptoms (bloating, irregular digestion, food sensitivities, brain fog) as gut-related until after treatment