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Nature 444 , 226229 (2006)

Symptoms flood back, often worse than before due to histamine accumulation

Depending on the extent of degeneration and tearing, the damaged segment of the labrum can be debrided (removed), repaired (labral repair), or reconstructed from cadaver tissue (labral reconstruction) (Figure 1)

In a mouse model with chemically-induced colitis, OX-A showed even better efficacy for healing than the monoclonal antibody infliximab, by reducing circulating cytokines, myeloperoxidase activity, lipopolysaccharide-binding protein, and cytokine gene expression [118]

Transcriptomic analysis Total RNA was isolated from root tissues using TRIzol Reagent (Invitrogen) following the manufacturers protocol