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Nat Commun 10(1):3143 Oh G, Wang A, Wang L et al (2023) POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling

Analysis of the promoter regions of SLC7A11 and SLC3A2 utilizing the online resource JASPAR ( revealed the presence of potential estrogen response element (EREs), resembling the ER binding motif, situated within the 1.5 kb promoter regions upstream of the transcription start sites of SLC7A11 and SLC3A2 (Fig

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Additionally, researchers have reported a substantial reduction in glutathione levels, as well as decreased activity of vital antioxidants such as superoxide dismutase and catalase, in the cerebrum, cerebellum, and hippocampus