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It is also used for heart disease, clogged arteries and decreasing the risk of re-clogging arteries after surgery, high triglyceride levels, lowering high homocysteine levels (which may contribute to heart disease), male infertility, diabetes, diabetic nerve damage, nerve damage in the hands or feet, sleep disorders, depression, mental disorders, schizophrenia, weak bones (osteoporosis), swollen tendons, AIDS, inflammatory bowel disease, diarrhea, asthma, allergies, a skin disease called vitiligo, and skin infections

In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation

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