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Another study reported that treatment with particulate -glucan substantially reduces MDSCs in tumor-bearing mice but increases the infiltrated M and DCs, thus inducing Th1 and CTL responses and suppressing the immunosuppressive effects of regulatory T cells (260)

10.1126/science.1261821 Science 30 ChenX.MarreroH.FreedmanJ

Functionally, zone 1 hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, b-oxidation of fatty acids, and cholesterol synthesis, while zone 3 cells are more important for glycolysis, lipogenesis, and cytochrome P-450based drug detoxification