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We utilized RNA sequencing, bioinformatic approaches, and both in vivo and in vitro experiments to confirm that TMAO promotes cholelithiasis by dysregulating hepatic cholesterol metabolism through its effects on the key regulatory genes apolipoprotein A4 ( APOA4) and proprotein convertase subtilisin/kexin type 9 ( PCSK9 )

High prevalence of exocrine pancreatic insufficiency in diabetes mellitus

Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Smith JD LL, et al

A four-ounce serving of codfish contains 4-7mg, and the same serving of chicken breast contains 3-5mg of L-Carnitine

Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase-2 and inflammatory factors