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Tipo de evidencia: ECA en humanos | Observacional

E., Ciaraldi, T

E., Zhao, Y., Xu, L., et al

A striking selectivity for AR binding sites based on the presence of adjacent binding motifs emerged in studies in which SUMO2 and 3 activity was inhibited pharmacologically: SUMOylation inhibition using ML-792 inhibited AR binding to genomic regions that contain multiple AREs, but enhanced AR binding to less accessible AREs that are enriched for pioneering transcription factor binding sites