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Direct causal links between specific Ca 2+ dynamics and macrophage fate outcomes, such as phagocytosis efficiency, intramacrophage bacterial killing, or apoptosis resistance, are largely absent in Klebsiella infection, with existing studies confined to mouse models and lacking human THP-1/PBMC validation, which is needed for clinical translation

In certain chronic liver diseases, typically cholestatic but including AIH, basal 24h urinary copper excretion may run 100200 g/24 h (1.63.2 mol/24 h)

Mol Neurobiol 59:40654105 Verhaegen D, Smits K, Osrio N, Caseiro A (2022) Oxidative stress in relation to aging and exercise

Similarly, "leaky gut" (increased intestinal permeability) can allow undigested food particles and bacterial toxins to pass into the bloodstream, potentially leading to systemic inflammation and indirect contributions to malodor

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