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In addition to affecting chondrocyte function, an overabundance of ROS induces mitochondrial DNA (mtDNA) damage and can also decrease the mtDNA repair capacity ( Figure 2 ) (112114)

It is 15 or more headache days per month

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To validate these phosphorylation sites of SahH, specific Ser and Thr residues were mutated to alanine to generate phospho-deficient variants of SahH which cannot accept a phosphate group

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