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Gene ontology (GO) functional annotation analysis of the 2,699 genes differentially expressed in response to B12 ( Figure S3 ) indicate that, in leukocytes of patients with moderate COVID-19, the vitamin stimulates the antiviral response induced by IFNs, regulates the exacerbated immune response induced by NF-kappaB and favors the inhibition of gene expression

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It is, therefore, contraindicated in patients with a history of or active peptic ulcer disease, GI bleeding, or GI perforation

A preliminary study of eleven consecutive patients evaluated individuals suffering from diabetic peripheral neuropathy who were treated with a combination of L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate (active Vitamin B6)