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In the later stages of critical illness, leptin levels typically decrease, leading to reduced IGF-1 production, disrupted FOXO regulation, and persistent suppression of AMPK signaling

Another study found a higher prevalence of C677T polymorphism in BD patients than healthy subjects, while patients with BD with early onset carried one copy of the T allele 62

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Mutations of IDH1/2 have been shown to promote self-renewal and suppress differentiation of normal HSCs, leading to the clonal expansion of stem/progenitor cells, known as pre-LSCs (67)

[DOI] [PubMed] [Google Scholar] 86.Hara N., Yamada K., Terashima M., Osago H., Shimoyama M., Tsuchiya M