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In Ingle J I, Bakland L K (eds) Endodontics

For instance, mutations in the NOD2 gene, a well-established genetic risk factor for CD in Western populations, are less common among African patients [69]

Phys Act Nutr

Furthermore, lactate itself acts as a signaling molecule by inhibiting histone deacetylase (HDAC) activity, thereby promoting the opening of epigenetic modifications in Th2-related genes (e.g., IL-4, IL-5) 123