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doi: 10.2337/db13-0417 93 WuXZhangHQiWZhangYLiJLiZet al

Varicose veins affect 2030% of adults and cause genuine morbidity

This conformational shift impairs the conversion of phosphoenolpyruvate (PEP), leading to the accumulation of glycolytic intermediates that fuel anabolic biosynthesis [96]