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Abbreviations: SAM, S-adenosyl-methionine

49%, 26/53 for Arm 2)

Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts

Although we agree with the authors of previous studies who have suggested that reduced synthesis of GSH induced by liver dysfunction and increased oxidative stress might cause HCC tissue to lose its capacity to provide protection against oxidative impairment [1,11,25,31], this cannot explain why our HCC patients had lower MDA and higher GSH levels in HCC tissue when compared to its adjacent normal liver tissue

4B) and increased mitochondrial ROS (Fig