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The enhanced antibody response was independent of changes in cytokine expression, and innate immune and lymphocyte counts

Neuroscience 148:535540

Specifically, expression of the gene ICOS was significantly negatively correlated with E2F6 expression, whereas U87 cell growth was reduced upon E2F6 knockout through short hairpin RNA (shRNA) [139]

Bhatti TR, Jatla M, Verma R, Bierly P, Russo PA, Ruchelli ED

Therefore, it is not possible to define the real activation status of the IGF-1 receptor signaling through the mere dosage of circulating IGF-1 levels