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Dynamics and line broadening: rapid conformational fluctuations within IDPs/IDRs, particularly on the millisecond to microsecond timescale, can lead to significant line broadening in NMR spectra, sometimes preventing direct studies of partially folded intermediates like molten globules

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This microenvironment further deteriorates during the degeneration process, not only severely affecting the survival and function of resident cells but also posing severe challenges for stem cell transplantation therapy

These vitamin stores arent removed from the body as quickly as water-soluble vitamins, most of which are eliminated via urine each day, according to Merck Manual