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Metformin treatment had a smaller and non-statistically significant effect in LC female PBMCs (Supplementary Figure S7B, CD4 p = 0.31, CD8 p = 0.42), where treatment reduced on average CD4 and CD8 T cell proliferation in female LC donors by 5.2% and 7.6% respectively

C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey

Another interesting experiment was published (227)

Tumor-expressed IDO recruits and activates MDSCs in a treg-dependent manner