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In Plant Sci

2.2 Transcriptional regulatory networks 2.2.1 Epigenetic dominance of the TOX/NR4A family In the fate determination of exhausted T cells, the transcription factors of the TOX and NR4A families serve as masterminds, reshaping the gene expression profile of T cells through epigenetic regulation, gradually plunging them into the quagmire of exhaustion (112, 113)

In parallel, traditional herbal formulations like Yijung-tang exert prebiotic-like effects, selectively enriching beneficial microbial taxa and promoting brown adipose tissue thermogenesis (Khakisahneh et al., 2023)