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Fahey JW, Zhang Y, Talalay P

Furthermore, the relevance of TRPs in NP will remain elusive until experimental studies (including knockdown or knockout animal models) demonstrate that an increase in TRP activity by exogenous TRP activators produces NP

This may be due to microglial hyperactivation, which has been observed in mice following QA administration [84]

Its relevance to women's hormonal health is indirect: gut mucosal integrity and chronic low-grade inflammation are now recognised as meaningful modulators of hormonal function particularly in PCOS, Hashimoto's thyroiditis, and perimenopause-associated metabolic disruption