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Monoclonal antibody therapy has been shown to help reduce symptoms and hospitalizations.

[110] Melatonin, perhaps through reduction of TNF secretion, has been shown to reduce cachexia in patients with metastatic solid tumors

The pale yellow keratin of non-pigmented hair appears white due to light refraction or reflection.34 Compared with pigmented hair, gray hair is thicker, stiffer, and more difficult to manage, grows faster, and is more susceptible to UV radiation damage, requiring greater protection.35 Alterations in hair fiber make it more difficult to maintain artificial color, leading many individuals to undergo repeated dyeing procedures, which may result in toxicity from artificial hair dyes.36 There are no sex-related differences in the prevalence of premature graying.37 In women, gray hair usually begins along the hairline, whereas in men it typically starts in the temporal region and sideburns

Their specific regulatory fibrotic effects need to be further investigated

FIGURE 1 TABLE 1 Table of shared pathogenic mechanisms in PD and metabolic dysfunction