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OLP, a DNMT inhibitor similar to SGI-1072, has been found to have a demethylation ability in D-galactose-induced senescent renal cells, effectively reducing DNMT1/3a/3b expression, decreasing the loss of antioxidant senescence factors KLOTHO and NRF2, and then ameliorating renal cellular senescence (198)

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Bauer AK, Faiola B, Abernethy DJ, Marchan R, Pluta LJ, et al

Homocysteine level determination in Kidney and End Stage Renal Disease was a double-blind, placebo-controlled clinical experiment in which 2056 patients who needed urgent renal replacement therapy and a rise in plasma homocysteine levels were given randomized supplements of folic acid, vitamin B12, and pyridoxine [90, 91]

J., Han X., Nagy L., Patti G