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In the phase 3 ELOQUENT-2 clinical trial in patients who had previously received one to three prior lines of therapy, PFS between groups favored elotuzumab with lenalidomide and dexamethasone versus lenalidomide and dexamethasone at 1 year (68% vs 57%) and 2 years (41% vs 27%)

Macrophage inflammatory protein-2 ( Mip2 ) (a functional murine homolog of Il8 which is not expressed in mice) showed the largest increase in expression following BH 4 supplementation with expression levels being 3.2-fold higher than control

It remains active across wide pH ranges and doesn't require carrier proteins for activity

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Structure-activity studies of the hGH (176191) lipolytic domain