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10.1016/j.jmb.2004.12.037 Hauptmann V, Weichert N, Menzel M, Knoch D, Paege N, Scheller J, Spohn U, Conrad U, Gils M: Native-sized spider silk proteins synthesized in planta via intein-based multimerization

Please note that the other tests mentioned do not directly measure vitamin B12 levels but instead help assess factors related to B12 deficiency or excess

In vitro experiment in vitro is a Latin phrase meaning 'in glass.' Natural killer (NK) cells - immune cells that release toxic chemicals to help destroy foreign invaders Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative damage - damage caused to large molecules (i.e., carbohydrates, protein, fat, DNA) by the presence of reactive oxygen species Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Pathogen - a disease-causing organism Phagocytes - immune cells that engulf and destroy foreign invaders Placebo - a chemically inactive substance Proliferation - an increase in the number or amount of something Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage T lymphocytes (T cells) - immune cells that detect specific pathogens and coordinate an immune response Authors and Reviewers Originally written in March 2016 by: Giana Angelo, Ph.D

Because it is largely free of those binding proteins, the analog stays active far longer than native IGF-1 a substantially extended half-life and more sustained systemic exposure

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