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Ghaseminejad, A., Ghaderi, A., Ghotloo, S., Akbari, H., et

They bypass potential absorption problems in the gut, ensuring more effective delivery of the vitamin into the bloodstream

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Furthermore, several preclinical studies have shown that metformin in combination with PD-1 inhibitors inhibits the growth of cancer cells in mouse models of different tumor types and leads to a significant increase in the number of tumor-infiltrating CD8 + T cells [397, 398]