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Immune dysregulation due to evasion strategies or host factors facilitates disease progression and drug resistance

Additionally, cholesterol metabolites, particularly oxysterols, modulate LXR and SREBP2 signaling, leading to altered lipid metabolism and metabolic reprogramming that further favors tumorigenesis [6, 11]

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The differences that existed between the evaluated study groups were assessed by performing an analysis of variance (One-way ANOVA) and the post hoc test (Tukey test) to conduct pair-wise comparisons

13.1%, p =0.03) than NUCs alone, but not in mild cases ( p =0.50)