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In brief, it is suggested that an elevated secretion of pro-inflammatory cytokines and diminished hepatoprotection by IL-6 might contribute to TVX-induced hepatotoxicity in the model, whereas the non-DILI reference drug LVX did not alter the cytokine profiles

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, et al

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Intestine and gastrointestinal system The historical context of BPC-157 (isolated from gastric juice) explains its most documented gastrointestinal application: gastric ulcers, colitis, and Crohn's disease in animal models