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Inversely, it has been shown that HBV infection induces changes in FXR expression and activity with modifications of FXR target genes expression in a humanized mouse model and in liver biopsies from chronically infected patients (172)

L J, N K, T L, Sj W, T S, H H, et al

176,177 Nagoshi et al

Rich sources include: Meat, especially liver and kidney Fish and shellfish Eggs and dairy products Fortified cereals and plant-based milk alternatives Because vitamin B12 is found primarily in animal products, individuals following a vegan or vegetarian diet may be at higher risk of deficiency

Indeed, deletion of GPX1, GPX2, or GPX3 in mice fails to affect development and survival [2]