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[The Working Group noted that the authors stated that this study was done in a new test system and there was uncertainty as to whether it possessed sufficient sensitivity

These include the polyol pathway and the hexosamine pathway (Figure 2, the pathways in blue), PKC activation, and the advanced glycation pathway [72]

In one small study, researchers discovered that patients with type 2 diabetes had lower levels of glutathione than healthy controls

[DOI] [PubMed] [Google Scholar] 58.Brunori M, Giuffre A, Forte E, Mastronicola D, Barone MC, Sarti P

In particular, the production of these oncometabolites was affected by the level of glutamine-derived -KG