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Since peptides are, by definition, short chains of amino acids, they are vulnerable to this digestive onslaught

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Mol Genet Metab 136:268273

With such alteration in overall GABAergic functioning, a drastic imbalance in excitation/inhibition develops across multiple brain regions [medial prefrontal cortex (Pleil et al., 2015)], amygdala circuit (Herman et al., 2016

Taken together this shows that although there are demonstrated signaling pathways in the communication between GM and the host and that this may include appetite control, the overall effect on whole animals is not fully understood