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This apparent selectivity may allow Ipamorelin to potentially stimulate growth hormone release by pituitary cells without necessarily triggering the release of cortisol or adrenocorticotropic hormone (ACTH)

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It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood