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The short answer is: very rarely, and to a dramatically lesser extent than other GHRPs

Immediate hypersensitivity reactions to beta-lactam antibiotics

Even though daily injections of sermorelin are capable of shutting GHRH production in neurons and synthesis of GHRH receptors in brain and pituitary, these effects are fully manifest after a period of time

Unmanaged stress, which can affect cortisol levels, sleep, appetite, recovery, and hormone signaling

[5] As a treatment, once-daily subcutaneous sermorelin (about 30 g/kg at bedtime) increased height velocity in some prepubertal children with idiopathic growth-hormone deficiency, with responses sustained over roughly 12 months and, in a few children, longer