Specifications Identity: Melanotan II (MT-II) cyclic -MSH analogue Synonyms: MT-II, Melanotan-2 CAS Number: 1036322-26-5 General Structure: Ac-Nle-cycloAspHisDPheArgTrpLysAsp-His-D-Phe-Arg-Trp-Lys-NH (lactam bridge) Molecular Weight: ~ 1024.2 g/mol Appearance: White to off-white lyophilized powder Purity: 99% (HPLC/MS verified) Form & Sizes: Common research and clinical vials 10 mg Manufacturing: GMP-compliant facility, USA Storage: 20 C, desiccated
This tissue has the added advantages of giving low background autofluorescence and being one of the last tissues to be invaded, postmortem, by bacteria such as C
Preparing PT-141 nasal spray Why nasal spray: Avoids injections (needle-phobic) More convenient Slightly faster onset (30-60 min quicker) Lower bioavailability (~30% vs ~100% injection) Need higher dose to compensate Nasal spray supplies needed: Empty nasal spray bottle (10-15ml) Reconstituted PT-141 (higher concentration recommended) Syringe for transferring Small funnel (optional) Concentration for nasal spray: Higher concentration better (less volume per dose) Reconstitute 10mg PT-141 in 1ml water = 10mg/ml Or even 10mg in 0.5ml = 20mg/ml (very concentrated) Allows smaller spray volume Fewer sprays needed per dose Nasal spray dosing: Inject: 1.5mg dose Nasal equivalent: 3-5mg (lower absorption) 0.3ml of 10mg/ml concentration = 3mg nasal 0.5ml of 10mg/ml = 5mg nasal Typical: 2-3 sprays per nostril (0.1ml per spray) See complete PT-141 nasal spray guide for men for detailed protocols
Studies have used MT-II in direct comparison with MT-1 to characterise how cyclisation of the -MSH pharmacophore core changes receptor subtype selectivity , establishing that constraining the heptapeptide into a cyclic conformation shifts selectivity toward MC3R/MC4R relative to the linear tridecapeptide that preferentially activates MC1R
GHK-Cu, complement for cutaneous protocols For research in skin regeneration, Melanotan II is combined with GHK-Cu
